IN THE SPOTLIGHT G34, Another Connection between MYCN and a Pediatric Tumor

نویسندگان

  • Miller Huang
  • William A. Weiss
چکیده

Authors’ Affi liation: University of California San Francisco, San Francisco, California Corresponding Author: William A. Weiss, University of California San Francisco, 1450 Third Street, Room 277, MC 0520, San Francisco, CA 94158-9001. Phone: 415-502-1694; Fax: 415-476-0133; E-mail: [email protected] doi: 10.1158/2159-8290.CD-13-0126 ©2013 American Association for Cancer Research. IN THE SPOTLIGHT G34, Another Connection between MYCN and a Pediatric Tumor Miller Huang and William A. Weiss Summary: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery , Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis. Cancer Discov; 3(5); 484–6. ©2013 AACR.

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G34, another connection between MYCN and a pediatric tumor.

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تاریخ انتشار 2013